Covid-19: Rich countries’ booster plans will impede global vaccination, experts say
نویسندگان
چکیده
Objective The objective of this study was to evaluate the characteristics and outcomes patients treated for gestational trophoblastic neoplasia (GTN) with second-line 5-day dactinomycin after failed first-line 8-day methotrexate. Methods From 1999 2017, methotrexate resistant GTN second line were identified at French Trophoblastic Disease Reference Center. Using univariate multivariate analysis, we significant predictive factors failure. Results A total 877 methotrexate, which 103 required Complete response observed in 78 (75.7% [95% confidence interval, 66.3–83.6]; P < 0.0001), whereas 25 needed third-line treatment, 13 resistance 12 post–dactinomycin relapse. Overall survival 100%. An interval greater than or equal 7 months between antecedent pregnancy termination initiation a factor significantly associated failure analysis (exact odds ratio, 9.17 1.98–50.70]; = 0.0029). No grades 4 5 adverse effects experienced most common toxicity being grade 1 nausea (14.6%). Conclusion Given 75.7% complete rate low-risk an overall 100% use should be favored as second-line, regardless human chorionic gonadotropin level time initiation. However, longer 6 encourage considering alternative therapeutic strategies.
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ژورنال
عنوان ژورنال: BMJ
سال: 2021
ISSN: ['0959-8138']
DOI: https://doi.org/10.1136/bmj.n2353